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Hyperpolarized Xenon for NMR and MRI Applications

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Published on: September 6, 2012

Hyperpolarized 89Y complexes as pH sensitive NMR probes.

Ashish K Jindal¹, Matthew E Merritt, Eul Hyun Suh

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.

Journal of the American Chemical Society

|January 28, 2010

Summary

This summary is machine-generated.

Hyperpolarized Yttrium-89 (89Y) complexes show promise as sensitive probes for in vivo pH measurements. Their long T(1) relaxation times enable enhanced Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) sensitivity.

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Area of Science:

Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI)

Background:

Hyperpolarization significantly enhances NMR/MRI sensitivity.
T(1) decay of magnetization limits hyperpolarized experiments.
The hyperpolarized Yttrium-89 (89Y) nucleus has a long T(1) relaxation time, making it suitable for in vivo applications.

Purpose of the Study:

To investigate the pH dependence of the 89Y chemical shift for two 89Y(III) complexes.
To demonstrate the utility of these complexes as sensitive spectroscopy/imaging agents for pH measurement.

Main Methods:

Synthesis and characterization of two distinct hyperpolarized 89Y(III) complexes.
Measurement of 89Y chemical shift as a function of pH.
Evaluation of the complexes' performance as pH-responsive probes.

Main Results:

The 89Y chemical shift demonstrated a clear dependence on pH for both complexes.
The long T(1) relaxation time of 89Y was confirmed, facilitating sensitive measurements.
The developed complexes showed potential for accurate in vivo pH determination.

Conclusions:

Hyperpolarized 89Y complexes are effective agents for pH-dependent spectroscopy and imaging.
These probes offer a sensitive method for non-invasive in vivo pH monitoring.
89Y-based agents represent a promising advancement in medical imaging and diagnostics.