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Increased plasma cyclic AMP concentrations in fasting man.

O D Mjøos, H Vik-Mo, T Henden

    Scandinavian Journal of Clinical and Laboratory Investigation
    |September 1, 1977
    PubMed
    Summary
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    During fasting, plasma cyclic AMP, free fatty acids (FFA), and glycerol increase initially, then stabilize. This rise in cyclic AMP is not linked to fat breakdown, suggesting alternative regulatory mechanisms.

    Area of Science:

    • Biochemistry
    • Human Physiology
    • Metabolic Studies

    Background:

    • Fasting alters metabolic substrates and signaling molecules.
    • Understanding the regulation of cyclic AMP (adenosine 3', 5' monophosphate) during fasting is crucial for metabolic research.

    Purpose of the Study:

    • To investigate the dynamic changes in plasma cyclic AMP, free fatty acids (FFA), glycerol, and glucose during prolonged fasting.
    • To determine if elevated plasma cyclic AMP during fasting is a consequence of stimulated lipolysis.

    Main Methods:

    • Healthy male students underwent 24, 48, and 72-hour fasts.
    • Plasma concentrations of cyclic AMP, FFA, glycerol, and glucose were measured at each time point.
    • Adipose tissue lipolysis was inhibited using a nicotinic acid analogue after 72 hours of fasting.

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    Main Results:

    • Plasma cyclic AMP, FFA, and glycerol concentrations significantly increased from 24 to 48 hours of fasting, with no further changes up to 72 hours.
    • Plasma glucose concentrations decreased progressively during the fasting period.
    • Inhibition of lipolysis after 72 hours did not alter plasma cyclic AMP levels.

    Conclusions:

    • Elevated plasma cyclic AMP during fasting is not directly stimulated by lipolysis.
    • Fasting induces distinct metabolic shifts, including changes in lipolysis and cyclic AMP, which are not causally linked.