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Related Experiment Video

Updated: Jun 16, 2026

An Assay for Quantifying Protein-RNA Binding in Bacteria

An Assay for Quantifying Protein-RNA Binding in Bacteria

Published on: June 12, 2019

Poly(A)-binding protein (PABP): a common viral target.

Richard W P Smith¹, Nicola K Gray

¹MRC Human Reproductive Sciences Unit, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK. richard.smith@hrsu.mrc.ac.uk

The Biochemical Journal

|January 28, 2010

Summary

Cytoplasmic poly(A)-binding protein (PABP) activity changes during viral infections. Viruses alter PABP stability, complex formation, and location, impacting gene expression regulation.

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Area of Science:

Molecular Biology
Virology
Biochemistry

Background:

Cytoplasmic poly(A)-binding protein (PABP) is crucial for mRNA translation and stability.
PABP plays a central role in regulating gene expression.

Purpose of the Study:

To review recent evidence on how viral infections alter PABP activity.
To highlight PABP's role as a central regulator of gene expression targeted by viruses.

Main Methods:

Literature review of studies examining PABP during viral infections.
Analysis of changes in PABP stability, complex formation, and intracellular localization.

Main Results:

Viral infections significantly alter PABP activity.
Changes include modifications to PABP's stability, complex formation, and intracellular localization.
Both RNA and DNA viruses target PABP.

Conclusions:

PABP is a key target for a wide range of viruses.
Altering PABP function is a viral strategy to manipulate host gene expression.