Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
Inhalational Anesthetics: Overview01:20

Inhalational Anesthetics: Overview

Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pressure-Volume-Derived Ventricular Energetics Across Mechanical Circulatory Support Strategies in Cardiogenic Shock.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same author

Pulmonary Artery Pulsatility Index Response to Vasodilator Challenge Predicts Early Right Ventricular Failure After Left Ventricular Assist Device.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same author

Letter to the Editor: As quiet as a baby… Feasibility in protocols for MRI management.

European radiology·2026
Same author

External validation of organ perfusion pressure as a prognostic marker in cardiogenic shock.

American heart journal·2026
Same author

Comparative evaluation of high-flow nasal oxygenation and conventional oxygen therapy in patients undergoing endoscopic retrograde cholangiopancreatography: a systematic review and meta-analysis of randomized clinical trials.

Minerva anestesiologica·2026
Same author

National insights on malignant hyperthermia: a SIAARTI survey on clinical practices, preparedness, and future directions.

Journal of anesthesia, analgesia and critical care·2025

Related Experiment Video

Updated: Jun 16, 2026

Guidelines for Elective Pediatric Fiberoptic Intubation
11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

Remifentanil in children.

Maria Sammartino1, Rossella Garra, Fabio Sbaraglia

  • 1Department of Anaesthesia and Intensive Care, Catholic University of Sacred Heart, Rome, Italy. marinasammartino@libero.it

Paediatric Anaesthesia
|January 28, 2010
PubMed
Summary

Remifentanil offers a versatile option for pediatric anesthesia, despite off-label concerns and limited trials. Further research is needed to confirm its safety and efficacy in neonates and children.

More Related Videos

Implantation of Electroencephalogram and Electrocardiogram Telemetry Devices in Neonatal Rabbit Kits
06:46

Implantation of Electroencephalogram and Electrocardiogram Telemetry Devices in Neonatal Rabbit Kits

Published on: February 28, 2025

Related Experiment Videos

Last Updated: Jun 16, 2026

Guidelines for Elective Pediatric Fiberoptic Intubation
11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

Implantation of Electroencephalogram and Electrocardiogram Telemetry Devices in Neonatal Rabbit Kits
06:46

Implantation of Electroencephalogram and Electrocardiogram Telemetry Devices in Neonatal Rabbit Kits

Published on: February 28, 2025

Area of Science:

  • Anesthesiology
  • Pediatric Pharmacology

Background:

  • Remifentanil is an opioid gaining acceptance in anesthesia.
  • Pediatric use faces challenges like off-label status and fear of adverse events.

Purpose of the Study:

  • To review the newer aspects of remifentanil for pediatric anesthesia.
  • To discuss its utility in various settings and potential risks.

Main Methods:

  • Literature review of remifentanil's use in pediatric patients.
  • Analysis of clinical experiences and pharmacokinetic data.

Main Results:

  • Remifentanil is used with various anesthetic agents for general anesthesia and total intravenous anesthesia (TIVA).
  • It shows utility in sedation for procedures and mechanical ventilation.
  • Pharmacokinetic characteristics appear consistent in neonates, but require further study.
  • Risks of tolerance and hyperalgesia in pediatrics need evaluation.

Conclusions:

  • Remifentanil is a versatile drug proposed as ideal for pediatric anesthesia.
  • Further pharmacokinetic and safety studies are essential for its optimal pediatric use.