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Related Experiment Videos

Serum TAG 72 levels in different human carcinomas.

M Correale1, I Abbate, G Gargano

  • 1Clinical Chemistry Laboratory, RIA Unit, Oncology Institute of Bari, Italy.

International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
|January 1, 1991
PubMed
Summary

Tumor-associated glycoprotein 72 (TAG 72) serum levels were measured in 326 cancer patients. TAG 72 showed high positivity in ovarian and gastric cancers, suggesting its use as a complementary tumor marker.

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Area of Science:

  • Oncology
  • Biochemistry
  • Clinical Diagnostics

Background:

  • Tumor markers are crucial for cancer diagnosis and monitoring.
  • TAG 72 is a known tumor-associated antigen.
  • Accurate and sensitive tumor markers are needed for various carcinomas.

Purpose of the Study:

  • To evaluate the diagnostic utility of serum TAG 72 levels in patients with various carcinomas.
  • To determine the sensitivity and specificity of TAG 72 as a tumor marker.
  • To explore the potential of TAG 72 in combination with other markers.

Main Methods:

  • Radioimmunoassay (RIA) kit was used to measure serum TAG 72 levels.
  • 326 patients with breast, gastrointestinal, and ovarian carcinomas were included.
  • A cut-off value of 5 U/mL was established for analysis.

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Main Results:

  • Overall sensitivity for neoplastic patients was 22% with 100% specificity in controls.
  • Highest positivity rates were observed in ovarian (63%) and gastric (58%) carcinomas.
  • TAG 72 levels showed significant correlation with specific cancer types.

Conclusions:

  • Serum TAG 72 demonstrates potential as a tumor marker, particularly for ovarian and gastric cancers.
  • TAG 72 can be considered as an adjunct to existing tumor markers for improved diagnostic accuracy.
  • Further research is warranted to explore the clinical application of TAG 72 in cancer management.