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Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular tachycardia.

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Related Experiment Video

Updated: Jun 16, 2026

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
05:47

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Published on: May 10, 2021

Mitral annular calcium causing mitral stenosis.

Gregg S Pressman1, Ashish Agarwal, Leonard E Braitman

  • 1Division of Cardiology, Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA. PressmanG@einstein.edu

The American Journal of Cardiology
|January 28, 2010
PubMed
Summary
This summary is machine-generated.

Mitral annular calcium (MAC) can worsen mitral valve function over time. Fifty percent of patients with severe MAC experienced increased mitral valve gradients, particularly those with higher baseline gradients and overall cardiac calcification.

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Last Updated: Jun 16, 2026

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
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Published on: February 4, 2021

Area of Science:

  • Cardiology
  • Echocardiography
  • Valvular Heart Disease

Background:

  • Mitral annular calcium (MAC) is frequently observed in echocardiography but rarely causes severe mitral stenosis.
  • The natural history of MAC and its impact on mitral valve function remain incompletely understood.
  • MAC is associated with systemic conditions like atherosclerosis and chronic kidney disease.

Purpose of the Study:

  • To investigate the longitudinal progression of mitral valve function in patients with severe mitral annular calcium.
  • To identify factors associated with the progression of mitral valve gradients in this cohort.

Main Methods:

  • A cohort of 37 outpatients with severe MAC (>5 mm) was studied.
  • Thirty-two patients underwent serial echocardiography over a mean follow-up of 2.6 years.
  • Mitral valve gradients and overall cardiac calcification were assessed.

Main Results:

  • Fifty percent (16 of 32) of followed patients showed progression of the mitral valve gradient.
  • Progression rates varied, with some experiencing rapid increases (up to 9 mm Hg/year).
  • Higher baseline gradients and greater overall cardiac calcification predicted faster progression.

Conclusions:

  • While severe mitral stenosis is uncommon in MAC patients, significant risk exists for those with baseline gradients and extensive calcification.
  • Younger age at initial echocardiogram may correlate with a faster rate of calcification progression.
  • Early identification of risk factors is crucial for managing MAC progression and potential valvular dysfunction.