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Updated: Feb 10, 2026

MALDI-ToF MS Method for the Characterization of Synthetic Polymers with Varying Dispersity and End Groups
Published on: October 3, 2025
Characterization of polyoxyalkylene block copolymers by combination of different chromatographic techniques and
Muhammad Imran Malik1, Bernd Trathnigg, Karin Bartl
1Institute of Chemistry, Karl-Franzens-University, Heinrichstrasse 28, A-8010 Graz, Austria.
Abstract:
Polyoxyalkylene diblock copolymers (consisting of PEO as hydrophilic block and PBO or PHO as hydrophobic block) are characterized by combination of two dimensional liquid chromatography and MALDI-TOF-MS. Liquid chromatography under critical conditions (LCCC) is used as first dimension and fractions are collected, mobile phase evaporated and diluted in the mobile phase used in the second dimension (SEC, LCCC or LAC). This two-dimensional chromatography in combination of MALDI-TOF-MS gives information about purity of reaction products, presence of the byproducts, chemical composition and molar mass distribution of all the products.
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