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Updated: Jun 16, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
Published on: February 28, 2012
[Thromboembolism risks in atrial fibrillation]
1Service de Cardiologie B, Pôle CTVH, Hôpital Trousseau, Université François Rabelais, Tours, France. d.babuty@chu-tours.fr
Insights
Atrial fibrillation increases mortality risk, but treatment focuses on preventing thromboembolism events like stroke. Identifying high-risk patients is crucial for effective management and improved outcomes.
Area of Science:
- Cardiology
- Vascular Medicine
- Public Health
Context:
- Atrial fibrillation (AF) is associated with a twofold increase in mortality, excluding cases of lone AF.
- The primary concern in AF is the elevated risk of thromboembolic events, particularly stroke.
- Specific conditions like rheumatic mitral valve disease or prosthetic valves significantly heighten this thromboembolic risk.
Purpose:
- To highlight the critical need for thromboembolism prevention in atrial fibrillation management.
- To underscore the importance of risk stratification tools like the CHADS2 score.
- To emphasize the proven efficacy of anticoagulant therapy in reducing AF-related morbidity and mortality.
Summary:
- Atrial fibrillation (AF) significantly elevates mortality risk, with thromboembolism, especially stroke, being a major complication.
- The CHADS2 score quantifies annual thromboembolism risk from 1.9% to 18.2%, aiding in patient stratification.
- Antivitamin K agents have demonstrated effectiveness in reducing mortality and morbidity, necessitating identification of at-risk individuals.
Impact:
- Establishes the central role of thromboembolism prevention in AF patient care.
- Reinforces the clinical utility of the CHADS2 score for risk assessment.
- Supports the continued use of anticoagulation therapy for managing AF-related complications.
Abstract:
The atrial fibrillation is linked to an overmortality (x2), except in patients with lone atrial fibrillation. The severity of atrial fibrillation is due to the risk of thromboembolism event, especially stroke. This risk is very high in presence of rhumatismal mitral valve pathology or prosthetic valve. The annual risk of thromboembolism has been evaluated and the CHADS2 score defined from 0 to 6 In function of the CHADS2 score the risk of thromboembolism event is 1.9 to 18.2%/year. Other factors of thromboembolism accident are actually evaluated such as renal insufficiency, proteinuria. The main objective of atrial fibrillation treatment is the prevention of thromboembolism event. The antivitamin K agents proved their efficiency in term of mortality and morbidity justifying to identify the patients at risk of thromboembolism event.
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