Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brain functional imaging in senile psychopathology.

G Rosadini1, P Cogorno, S Marenco

  • 1Institute of Neurophysiopathology, University of Genoa, Italy.

International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology
|January 1, 1991
PubMed
Summary

Quantified electroencephalogram (EEG) and regional cerebral blood flow (rCBF) mapping can detect brain aging and pathology. Accurate selection of healthy controls is crucial for identifying subtle functional changes in dementia and cerebrovascular disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic role of immunohistochemical overexpression of the p16 protein in women under the age of 35 and diagnosed with HSIL (CIN2) subjected to "cervix sparing" excision.

European review for medical and pharmacological sciences·2021
Same author

A kinetics-based approach to amyloid PET semi-quantification.

European journal of nuclear medicine and molecular imaging·2020
Same author

Clinical and MRI Predictors of Conversion From Mild Behavioural Impairment to Dementia.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2020
Same author

Italian consensus recommendations for a biomarker-based aetiological diagnosis in mild cognitive impairment patients.

European journal of neurology·2019
Same author

Could arterial spin labelling perfusion imaging uncover the invisible in N-methyl-d-aspartate receptor encephalitis?

European journal of neurology·2019
Same author

Semi-quantification and grading of amyloid PET: A project of the European Alzheimer's Disease Consortium (EADC).

NeuroImage. Clinical·2019

Area of Science:

  • Neuroscience
  • Gerontology
  • Medical Imaging

Background:

  • Quantified electroencephalogram (EEG) and regional cerebral blood flow (rCBF) are established methods for brain function assessment.
  • These techniques offer minimal patient discomfort and can be routinely applied.
  • Automated mapping systems facilitate topographical analysis and real-time statistical comparisons.

Purpose of the Study:

  • To investigate systematic changes in topographical EEG and rCBF parameters during normal aging.
  • To identify characteristic functional brain abnormalities in dementia and cerebrovascular disease.
  • To assess the impact of risk factors like hypertension on cerebral blood flow and EEG patterns.

Main Methods:

  • Utilizing quantified electroencephalogram (EEG) and regional cerebral blood flow (rCBF) measurements.

Related Experiment Videos

  • Employing a fully automated mapping system for topographical analysis of EEG and rCBF data.
  • Performing real-time statistical comparisons against age-matched healthy control groups.

    • Main Results:

    • Dementias and cerebrovascular pathologies exhibit distinct brain functional abnormalities detectable through EEG and rCBF.
    • Systematic modifications in the topographic distribution of EEG and rCBF parameters are observed in aging and disease states.
    • The sensitivity of statistical detection of abnormalities is significantly influenced by the selection of healthy aged controls.

    Conclusions:

    • Topographical EEG and rCBF analysis are valuable tools for functional brain exploration in aging and neurological conditions.
    • Accurate characterization of normal aging is essential for reliably detecting pathological changes.
    • Careful selection of age-matched controls enhances the statistical power to identify subtle functional deficits in neurological diseases.