Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Monocyte kinetics in rabbits.

M Ohgami1, C M Doerschuk, R P Gie

  • 1University of British Columbia Pulmonary Research Laboratory, St. Paul's Hospital, Vancouver, Canada.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Socioeconomic Disadvantage, Mental Health and Substance Use in Young Men in Emerging Adulthood.

Behavioral medicine (Washington, D.C.)·2019
Same author

Conductance quantisation in patterned gate In<sub>0.75</sub>Ga<sub>0.25</sub>As structures up to 6  ×  (2e <sup>2</sup>/h).

Journal of physics. Condensed matter : an Institute of Physics journal·2019
Same author

Laparoscopic Ovarian Transposition.

Journal of minimally invasive gynecology·2016
Same author

Mammaglobin B (SCGB2A1) is a novel tumour antigen highly differentially expressed in all major histological types of ovarian cancer: implications for ovarian cancer immunotherapy.

British journal of cancer·2013
Same author

Inter-proximal damage.

British dental journal·2012
Same author

The response of human ectomesenchymal dental pulp stem cells to cisplatin treatment.

International endodontic journal·2011
Same journal

Thoroughbred horses susceptible to Recurrent Exertional Rhabdomyolysis have elevated skeletal muscle mitochondrial capacities.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Change in Neutrophil-to-Lymphocyte Ratio after acute and chronic exercise: A Systematic Review and Meta-Analysis.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Ankylosing spondylitis and muscle sympathetic nerve activity: a case study.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Intracranial vasomotor and blood flow responses to light intensity aerobic exercise in young adults: a 4D flow MRI study.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Comparative assessments of the COSMED adaptive mixing chamber vs. breath-by-breath methods for oxygen uptake measurements in recreationally active adults.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Can we assess exercise metabolism from skin? Metabolomic profiles in skin dialysate collected during exercise.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
See all related articles

The lung sequesters monocytes, forming a large marginating pool. This study confirms the lung

Area of Science:

  • Immunology
  • Hematology
  • Pulmonary Medicine

Background:

  • Previous studies suggest the lung sequesters monocytes, impacting their kinetics.
  • Concerns exist that monocyte isolation procedures may alter their behavior.
  • The lung is the initial capillary bed for intravenously injected monocytes.

Purpose of the Study:

  • To investigate the distribution and behavior of isolated monocytes in vivo.
  • To determine if the lung harbors a significant marginating pool of monocytes.
  • To assess monocyte kinetics independent of isolation artifacts.

Main Methods:

  • Comparison of radiolabeled monocyte distribution after intravenous vs. intra-arterial injection.
  • Quantification of monocyte recovery in various organs at 10 minutes post-injection.

Related Experiment Videos

  • Analysis of lung-to-blood monocyte ratios and retention proportionality.

    • Main Results:

    • First-pass lung extraction of monocytes was 86.5%.
    • After 10 minutes, lungs retained 35.5% (IV) and 29.7% (IA) of monocytes.
    • The lung marginating pool was 5-7 times larger than the circulating pool.

    Conclusions:

    • The lung contains a substantial marginating pool of monocytes.
    • Monocyte retention in the lung correlates with erythrocyte transit time.
    • Monocytes may accumulate in the lung for subsequent migration into lung tissues.