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Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
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Updated: Jun 16, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

New developments in massive transfusion in trauma.

Sarah E Greer1, Kurt K Rhynhart, Rajan Gupta

  • 1Dartmouth Hitchcock Medical Center, Departments of Surgery, USA.

Current Opinion in Anaesthesiology
|January 28, 2010
PubMed
Summary
This summary is machine-generated.

Early, aggressive treatment of trauma-induced coagulopathy with higher ratios of plasma and platelets to red blood cells improves survival. This approach reduces mortality in massive transfusion patients.

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Last Updated: Jun 16, 2026

Microfluidics in Assessing Platelet Function
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Published on: November 8, 2024

Massive Pontine Hemorrhage by Dual Injection of Autologous Blood
06:33

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Published on: May 29, 2021

Integrated Compensatory Responses in a Human Model of Hemorrhage
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Integrated Compensatory Responses in a Human Model of Hemorrhage

Published on: November 20, 2016

Area of Science:

  • Trauma resuscitation
  • Hemorrhagic shock management
  • Coagulopathy treatment

Background:

  • Massive transfusion in trauma patients carries a high risk of preventable death.
  • Coagulopathy of trauma is a critical factor influencing outcomes.
  • Optimal resuscitation strategies are continuously evolving.

Purpose of the Study:

  • To review recent advances in early recognition and treatment of trauma-related coagulopathy.
  • To discuss ongoing research in defining optimal resuscitation strategies for trauma patients.
  • To highlight improvements in managing patients requiring massive transfusion.

Main Methods:

  • Review of current literature on damage control resuscitation.
  • Analysis of evidence regarding blood product ratios in massive transfusion.
  • Evaluation of adjuncts and point-of-care testing in trauma care.

Main Results:

  • Damage control resuscitation involves correcting hypothermia, acidosis, and coagulopathy with early transfusion.
  • Higher ratios of plasma and platelets to red blood cells improve mortality and reduce overall blood product usage.
  • Adjuncts like factor VIIa and point-of-care testing may aid in guiding transfusion therapy.

Conclusions:

  • Early and aggressive treatment of coagulopathy is a key focus in evolving resuscitation strategies.
  • Increased ratios of plasma and platelets to red blood cells show beneficial outcomes in trauma-related mortality.
  • Optimized resuscitation strategies are crucial for improving survival in critically injured patients.