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In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
Published on: January 22, 2020
A practical guide to vaccinating the inflammatory bowel disease patient
Sharmeel K Wasan1, Stacey E Baker, Paul R Skolnik
1Boston Medical Center, Section of Gastroenterology, Department of Gastroenterology, Boston University School of Medicine, Boston, Massachusetts 02118, USA. Sharmeel.Wasan@bmc.org
Patients with inflammatory bowel disease (IBD) on immunosuppressants face higher infection risks. Vaccinations before and during therapy are crucial for preventing infections in Crohn
Area of Science:
- Immunology
- Gastroenterology
- Infectious Diseases
Background:
- Corticosteroids, immune modulators, and biologics are standard IBD treatments.
- These therapies increase patient susceptibility to infections.
- Many infections in IBD patients are vaccine-preventable.
Purpose of the Study:
- To review immunization issues in IBD patients.
- To provide a clinical guide for vaccination strategies.
- To ensure appropriate vaccinations before and during immunosuppressive therapy.
Main Methods:
- Literature review on IBD immunizations.
- Analysis of current vaccination guidelines for IBD.
- Synthesis of practical recommendations for clinicians.
Main Results:
- IBD patients on immunosuppressants require specific vaccination protocols.
- Pre-therapy vaccination is essential for optimal protection.
- Ongoing vaccination assessment is necessary during treatment.
Conclusions:
- Vaccination is a critical component of IBD patient care.
- Proactive immunization strategies reduce infection risk.
- Clinicians need clear guidance on IBD patient vaccination.
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