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Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells
Published on: July 10, 2019
Injury-induced neural stem/progenitor cells in post-stroke human cerebral cortex
Daisuke Nakayama1, Tomohiro Matsuyama, Hatsue Ishibashi-Ueda
1Department of Cerebrovascular Disease, National Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565 Japan.
The European Journal of Neuroscience
|January 28, 2010
Summary
Human brain stroke triggers neural stem cell activity in the cerebral cortex. Supporting these cells may improve recovery after stroke, though mature cells were not observed long-term.
Area of Science:
- Neuroscience
- Regenerative Medicine
- Stroke Research
Background:
- Stroke can induce neurogenesis, the creation of new neurons.
- Supporting endogenous neurogenesis shows promise for improving stroke outcomes in animal models.
Purpose of the Study:
- To investigate the presence and characteristics of neural stem/progenitor cells in the human cerebral cortex following ischemic stroke.
- To analyze the temporal dynamics and localization of these cells post-stroke.
Main Methods:
- Analysis of autoptic human brain tissue after cardiogenic embolism-induced stroke.
- Immunohistochemical detection of nestin- and musashi-1-positive cells, markers for neural stem/progenitor cells.
Main Results:
- Nestin- and musashi-1-positive cells, potential neural stem/progenitor cells, were identified at ischemic lesion sites starting from day 1 post-stroke.
- These cell populations exhibited distinct spatial distributions and temporal expression patterns.
- No surviving differentiated mature neural cells were observed in the previously ischemic region by 90 days post-stroke.
Conclusions:
- The human cerebral cortex demonstrates a regional regenerative response following ischemic stroke, characterized by the induction of neural stem/progenitor cells.
- These findings support the potential importance of fostering the survival and differentiation of endogenous neural stem/progenitor cells for therapeutic strategies in post-stroke human brains.
