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Published on: June 11, 2012
Effect of bariatric surgery on circulating chemerin levels
1Department of Medicine I, Medical University Innsbruck, 6020 Innsbruck, Austria.
European Journal of Clinical Investigation
|January 29, 2010
Summary
Significant weight loss through bariatric surgery reduced circulating chemerin levels and subclinical inflammation. This suggests a link between reduced chemerin and improved metabolic health in obese patients.
Area of Science:
- Endocrinology
- Metabolic Syndrome
- Inflammation Research
Background:
- Obesity is linked to subclinical inflammation, a key factor in associated disorders.
- Chemerin, a chemoattractant protein, plays a role in adipose tissue function.
Purpose of the Study:
- To investigate the impact of substantial weight loss on circulating chemerin levels.
- To assess changes in chemerin and inflammation markers post-bariatric surgery.
Main Methods:
- Study included 32 obese patients undergoing bariatric surgery.
- Measurements were taken before and approximately 18 months after gastric banding or bypass surgery.
Main Results:
- Weight loss improved lipid and glucose metabolism and increased adiponectin.
- Circulating chemerin levels significantly decreased post-surgery (P < 0.01).
- High-sensitivity C-reactive protein (hs-CRP), an inflammation marker, also significantly reduced (P < 0.01).
Conclusions:
- Weight-loss-induced reduction in chemerin may contribute to decreased macrophage recruitment in adipose tissue.
- This reduction in inflammation could partially explain the long-term benefits of weight loss in obesity.
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