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Related Concept Videos

Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...

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Related Experiment Video

Updated: Jun 16, 2026

Induction of Leptomeningeal Cells Modification Via Intracisternal Injection
05:55

Induction of Leptomeningeal Cells Modification Via Intracisternal Injection

Published on: May 7, 2020

[Drug-induced aseptic meningitis].

Katherina Podlekareva Farr1, Christian Backer Mogensen

  • 1Onkologisk Afdeling D, Arhus Universitetshospital, Arhus Sygehus, DK-8000 Arhus, Denmark. katherinap@hotmail.com

Ugeskrift for Laeger
|January 29, 2010
PubMed
Summary

Drug-induced aseptic meningitis is a rare side effect. Ibuprofen can cause recurrent meningitis, presenting with fever and neurological symptoms, requiring careful diagnosis based on drug history and negative tests.

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Drug-induced aseptic meningitis is a rare adverse drug reaction.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are implicated in some cases.

Observation:

  • A patient experienced four distinct episodes of meningitis.
  • Each episode was temporally associated with ibuprofen use for pain management.
  • Symptoms included fever and cerebrovascular events.

Findings:

  • Recurrent meningitis was directly linked to ibuprofen administration.
  • Diagnosis relies on the temporal relationship between ibuprofen intake and symptom onset.
  • Negative microbiological findings are crucial for diagnosis.

Implications:

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Neisseria meningitidis Infection of Induced Pluripotent Stem-Cell Derived Brain Endothelial Cells
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Neisseria meningitidis Infection of Induced Pluripotent Stem-Cell Derived Brain Endothelial Cells

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Related Experiment Videos

Last Updated: Jun 16, 2026

Induction of Leptomeningeal Cells Modification Via Intracisternal Injection
05:55

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Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
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Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

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Neisseria meningitidis Infection of Induced Pluripotent Stem-Cell Derived Brain Endothelial Cells
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  • Highlights ibuprofen as a potential cause of recurrent aseptic meningitis.
  • Emphasizes the importance of considering drug history in meningitis diagnosis.
  • Suggests careful patient monitoring for NSAID-associated neurological adverse events.