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Pneumococcal soft-tissue infections: possible association with connective tissue diseases
M J DiNubile1, M A Albornoz, R J Stumacher
1Department of Medicine, Cooper Hospital/University Medical Center, Camden, NJ.
The Journal of Infectious Diseases
|April 1, 1991
Summary
Streptococcus pneumoniae, a common cause of pneumonia, can also lead to soft-tissue infections, particularly in immunocompromised individuals. This study highlights its underrecognized role, especially in patients with connective tissue diseases.
Area of Science:
- Infectious Diseases
- Microbiology
- Dermatology
Background:
- Streptococcus pneumoniae is primarily known for causing respiratory infections.
- Soft-tissue infections are typically attributed to other bacterial pathogens.
Observation:
- Twelve cases of soft-tissue infections caused by Streptococcus pneumoniae were identified over four years.
- Infections occurred in various sites, including skin, fascia, tongue, epiglottis, thyroid, brain, and breast.
- Pneumococcal bacteremia was present in 50% of cases.
Findings:
- Streptococcus pneumoniae was isolated from infected soft tissues in all cases, with or without bacteremia.
- Patients with connective tissue diseases, particularly systemic lupus erythematosus, were disproportionately affected.
- Corticosteroid use and HIV infection were identified as risk factors.
Implications:
- Streptococcus pneumoniae should be considered a potential cause of soft-tissue infections, especially in at-risk populations.
- Early recognition and appropriate antibiotic treatment are crucial for managing these infections.
- Further research is needed to understand the pathogenesis and epidemiology of pneumococcal soft-tissue infections.