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Updated: Jun 16, 2026

Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide
Published on: May 12, 2023
Stilbene analogs as inducers of apolipoprotein-I transcription
Henrik C Hansen1, Fabrizio S Chiacchia, Reena Patel
1Resverlogix Corp., Suite 202, 279 Midpark Way SE, Calgary, Alberta, T2X 1M2, Canada. henrik@resverlogix.com
Abstract:
Based on the naturally occurring stilbene, Resveratrol, a series of novel stilbene derivatives were synthesized, which have the ability to induce the expression of the ApoA-I gene. Several compounds equally or more potent than Resveratrol were identified. trans-4,4'-dihydroxy-2-methoxystilbene was the most potent (4.6x more potent than Resveratrol). These compounds provide an early lead into new drugs to treat atherosclerosis.
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