Related Experiment Video
Updated: Jun 16, 2026

Assessment of Kidney Function in Mouse Models of Glomerular Disease
Published on: June 30, 2018
Estimation of age from sclerotic glomeruli
Naoki Fukuda1, Yoichi Suzuki, Kaoru Sato
1Department of Legal Medicine, Graduate School of Medicine, Chiba University, Chu-o-ku, Chiba, Japan. shellingford.4869@hotmail.co.jp
Abstract:
Glomerular sclerosis is one of the age-related causes of nephron damage. Histological studies of cadaver kidneys in several ethnic groups have shown that there is a consistent relationship between the percentage of sclerotic glomeruli (PSG) and age. However, no study regarding this relationship in the Japanese population has been reported to date. Here, we investigated such relationship in 150 Japanese cadavers that were selected regardless of clinical history. The straight line regression was estimated as follows: Age=23.3+1.36 x APSG (APSG: arcsine-transformed PSG). The R(2) value of the regression line was 0.598. The diagnostic test with the PSG value (cutoff=0.6%) for the age stratum (cutoff=33 years old) showed very high sensitivity (100%) and specificity (97.6%). From the results, PSG appears to be useful for the estimation of a cadaver's age in the Japanese population.
Related Concept Videos
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance

