Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Depressive Disorders: MDD and Dysthymia

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...

Depression: Overview

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

Depressive Disorders: Etiology

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

Negative and Cognitive Symptoms of Schizophrenia

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...

Disorders of the Female Reproductive System

Disorders of the Female Reproductive System

The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...

Stress and Mental Health

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[The psychological taking charge of the oncological patient: a 3 years study on the activities of psychologists of the Piedmont and Aosta Valley Oncology Network.]

Recenti progressi in medicina·2022

Same author

Italian adaptation of the brief modified experiences in close relationships scale in a sample of cancer patients: factor analysis and clinical implications.

Research in psychotherapy (Milano)·2020

Same author

Psychological characteristics of early-stage melanoma patients: a cross-sectional study on 204 patients.

Melanoma research·2017

Same author

Fibro-fog.

Clinical and experimental rheumatology·2016

Same author

Pharmacological management of depression in patients with cancer: practical considerations.

Drugs·2013

Same author

Antidepressant up-titration: pharmacological and psychological considerations.

Expert opinion on drug safety·2012

Search research articles

Related Experiment Video

Updated: Jun 16, 2026

Burn Injury-Induced Pain and Depression-Like Behavior in Mice

Burn Injury-Induced Pain and Depression-Like Behavior in Mice

Published on: September 29, 2021

Symptom cluster: Depression and pain.

Riccardo G V Torta¹, Jacopo Munari

¹Clinical and Oncological Psychology, University of Turin, Turin, Italy. walgianni@hotmail.it

Surgical Oncology

|January 29, 2010

Summary

This summary is machine-generated.

Pain and depression frequently co-occur in cancer patients. Combined therapies, including antidepressants, are more effective for managing pain and improving mood in oncology patients, particularly the elderly.

More Related Videos

Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder

Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder

Published on: July 7, 2023

Quantifying Pain Location and Intensity with Multimodal Pain Body Diagrams

Quantifying Pain Location and Intensity with Multimodal Pain Body Diagrams

Published on: July 7, 2023

Related Experiment Videos

Last Updated: Jun 16, 2026

Burn Injury-Induced Pain and Depression-Like Behavior in Mice

Burn Injury-Induced Pain and Depression-Like Behavior in Mice

Published on: September 29, 2021

Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder

Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder

Published on: July 7, 2023

Quantifying Pain Location and Intensity with Multimodal Pain Body Diagrams

Quantifying Pain Location and Intensity with Multimodal Pain Body Diagrams

Published on: July 7, 2023

Area of Science:

Oncology
Psychiatry
Pain Management

Background:

Pain and depression are highly associated in cancer patients, with reciprocal influences.
Somatic symptoms of depression include pain, while chronic pain involves emotional and cognitive aspects like anxiety and depressed mood.

Purpose of the Study:

To discuss the reciprocal influence of pain and depression in oncology.
To explore the role of antidepressant drugs (ADs) in managing oncological pain.
To evaluate the effectiveness of combined antalgic therapies.

Main Methods:

Review of biological, emotional, and cognitive mechanisms linking pain and depression.
Discussion of pharmacological treatments, specifically antidepressant drugs (ADs).
Analysis of evidence for combined antalgic therapies (analgesics, ADs, psychotherapies).

Main Results:

Antidepressant drugs (ADs) offer direct and indirect pain mitigation and improve cognitive attitudes toward pain.
Combined antalgic therapies demonstrate greater effectiveness than single treatments.
Combined therapies are particularly effective in elderly oncological patients.

Conclusions:

The interplay between pain and depression in oncology requires integrated treatment approaches.
Combined antalgic therapies, including analgesics and antidepressants, are crucial for comprehensive pain and mood management in cancer patients.
Multimodal treatment strategies are essential, especially for vulnerable populations like elderly cancer patients.