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Updated: Jun 16, 2026

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Standardisation of 18F by a coincidence method using full solid angle detectors.

Youcef Nedjadi1, Claude Bailat, Yvan Caffari

  • 1Institut de Radiophysique Appliquée, Lausanne, Switzerland. youcef.nedjadi@chuv.ch

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
|January 29, 2010
PubMed
Summary

A new 4πβ-4πγ coincidence counting system accurately standardizes Fluorine-18 (18F) radioactivity. This method offers reliable quantification for nuclear medicine applications.

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Area of Science:

  • Nuclear physics
  • Radiochemistry
  • Metrology

Background:

  • Accurate standardization of radionuclides is crucial for nuclear medicine.
  • Short-lived radionuclides like Fluorine-18 (18F) require precise activity measurements.
  • Existing methods for 18F standardization have varying degrees of uncertainty.

Purpose of the Study:

  • To evaluate a newly developed 4πβ-4πγ coincidence counting system for standardizing 18F.
  • To compare the performance of the new system against established methods.
  • To demonstrate the system's capability for routine standardization of short-lived radionuclides.

Main Methods:

  • Standardization of 18F using a 4πβ-4πγ coincidence system with a plastic scintillator and NaI(Tl) detector.
  • Comparison with 4πγ NaI(Tl) integral counting, Monte Carlo simulations, and the CIEMAT-NIST method.

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  • Secondary measurements using an IG11 ionization chamber traceable to the International System of Reference.

    • Main Results:

    • The 4πβ-4πγ coincidence system achieved near-full detection efficiency in the beta channel.
    • Results from the new system showed close agreement with ionization chamber measurements.
    • The 18F activity values were compatible within one standard deviation with other primary measurement methods.

    Conclusions:

    • The developed 4πβ-4πγ coincidence counting system provides accurate standardization of 18F.
    • The system is suitable for routine use in quantifying short-lived radionuclides for nuclear medicine.
    • This work validates the reliability of the new coincidence counting technique for metrology.