Related Experiment Video

Updated: Jun 16, 2026

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
07:46

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse

Published on: October 25, 2024

Development, regulation and functional capacities of Th17 cells

Keiji Hirota1, Bruno Martin, Marc Veldhoen

  • 1MRC National Institute for Medical Research, Mill Hill, London, UK.

Seminars in Immunopathology
|January 29, 2010
PubMed

T helper (Th) 17 cells have been classified as a new lineage, distinct from Th1, Th2 and Treg. Their development requires a unique combination of cytokines and depends on distinct intracellular events, resulting in the production of the signature cytokines interleukin (IL)-17A, IL-17F and IL-22. The differential cytokine expression patterns in Th cells suggest a division of labour in the response against a variety of pathogens. Th17 have an important function in the host-defense-response against extracellular pathogens, but they also have become notorious for their role in the pathogenesis of many autoimmune and allergic disorders. Animal models of autoimmune disorders have shown that Th17 effector molecules and transcription factors play a crucial role in both development and maintenance of the disease. The discovery of Th17 not only enhanced our insight into these disorders but also placed a Th subset at the interface between the innate and adoptive immune systems with the potential to regulate subsequent immunity against pathogens.

More Related Videos

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets07:12

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...