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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

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Published on: August 30, 2018

Variability in outpatient antimicrobial consumption in Israel.

O Nitzan¹, M Low, I Lavi

¹Internal Medicine Ward C, Haemek Medical Center, Afula, Israel.

|January 29, 2010

Summary

Antibiotic use in Israeli outpatient settings decreased from 2003-2005, with children consuming the most. Diabetes mellitus prevalence was the only factor linked to variations in antibiotic consumption.

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Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance

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Published on: July 21, 2023

Area of Science:

Public Health
Epidemiology
Pharmacology

Background:

Antibiotic consumption significantly impacts microbial resistance patterns.
Nationwide data on outpatient antibiotic use in Israel were previously limited.
Understanding regional variations in antibiotic prescribing is crucial for public health initiatives.

Purpose of the Study:

To analyze antibiotic utilization trends in Israel's outpatient settings.
To identify factors influencing antibiotic consumption patterns.
To provide data for optimizing antibiotic stewardship programs.

Main Methods:

Calculated defined daily doses per 1,000 inhabitants per day (DID) for antibiotic use from 2003-2005.
Utilized prescription data from "Clalit Health Services," covering 55% of Israel's population.
Analyzed trends in antibiotic use across age groups, antibiotic classes, and geographic districts, including multivariate analysis.

Main Results:

A significant decrease in overall antibiotic use (1.8-8.2%) was observed across districts between 2003 and 2005.
Children (<=18 years) accounted for over half of all antibiotic prescriptions.
Higher diabetes mellitus prevalence was the sole significant variable associated with increased antibiotic use; significant regional variations in consumption were noted.

Conclusions:

Outpatient antibiotic use declined in Israel between 2003 and 2005.
Children exhibited the highest antibiotic consumption rates.
Geographic disparities in antibiotic use were substantial, with physician preferences, local practices, and patient expectations likely driving these differences.