Related Experiment Video
Updated: Jun 16, 2026

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
Published on: October 17, 2014
Delta-catenin affects the localization and stability of p120-catenin by competitively interacting with E-cadherin
Ilhwan Yang1, Ockyoung Chang, Qun Lu
1The College of Pharmacy and Research Institute for Drug Development, Chonnam National University, Gwangju, 500-757, Korea.
Abstract:
E-cadherin is a member of the cadherin family of Ca(2+)-dependent cell-cell adhesion molecules. p120-Catenin and delta-catenin are known to bind to similar juxtamembrane regions of E-cadherin, and p120-catenin is known to stabilize E-cadherin. However, the function of competition between p120-catenin and delta-catenin for E-cadherin has not been fully explained. In this report, we show that cells overexpressing delta-catenin contain less p120-catenin than control cells at the cell-cell interface and that this causes the relocalization of p120-catenin from the plasma membrane to the cytosol. We show that successful binding by either one to E-cadherin adversely affects the stability of the other.
Related Concept Videos
Catenins
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the adherens...
Cadherins in Tissue Organization
Cell Sorting During Development
Cell sorting plays an...
Structure of Cadherins
Tension Response at Adherens Junctions
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin homology) domains...
Cytoskeletal Coordination in Cell Migration
Intracellular Signaling Affects Focal Adhesions
Some...

