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Updated: Jun 16, 2026
08:56
Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale
Published on: August 16, 2018
New cucurbitane-type triterpenoids from Bryonia aspera
Shamim Sahranavard1, Farzaneh Naghibi, Karsten Siems
1Pharmacognosy Department, School of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. ssahranavard@itmrc.org
Planta Medica
|January 29, 2010
Summary
Phytochemical analysis of Bryonia aspera roots revealed two novel cucurbitacins and ten known compounds. These findings contribute to understanding the chemical diversity of this plant species.
Area of Science:
- Phytochemistry
- Natural Product Chemistry
- Organic Chemistry
Background:
- The study focuses on the phytochemical investigation of Bryonia aspera root extracts.
- Bryonia aspera is a plant species with potential medicinal properties.
Discussion:
- Isolation and structure elucidation of two new cucurbitacins (compounds 1, 2).
- Identification of eight known cucurbitane derivatives (compounds 6-13).
- Characterization of bryonolic acid (a pentacyclic triterpene, compound 5) and two hydroxybenzoic acid amides (compounds 3, 4).
Key Insights:
- The research expands the known chemical constituents of Bryonia aspera.
- Two previously undescribed cucurbitacin compounds were identified.
- Advanced spectroscopic methods, including 2D NMR, were crucial for structure determination.
Outlook:
- Further research could explore the biological activities of the isolated compounds.
- This study provides a chemical basis for potential ethnobotanical uses of Bryonia aspera.
- Comparative phytochemical analysis with related species may reveal evolutionary insights.
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