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Updated: Jun 16, 2026

Isolation of Primary Mouse Trophoblast Cells and Trophoblast Invasion Assay
Published on: January 8, 2012
[Expression of DC-SIGNR in the primary trophoblast cells and its significance]
Qin Zhang1, Jun-nan Li, Zhi-qing Linag
1Department of Obesterics and Gynecology, South-west Hospital, Third Military Medical University, Chongqin, China. zhangqin2003212@tom.com
Aim:
To study the expression of DC-SIGNR in human placenta and trophoblast cells cultured in vitro, and provided a basis for experiment in vitro aiming to investigate the mechanism of receptor-mediated intrauterine transmission.
Methods:
Primary culture system of human chorionic trophoblast cells were established. The expression of DC-SIGN and DC-SIGNR was determined by Immunohistochemistry (IHC) stain.
Results:
DC-SIGNR was mainly expressed in the membrane and plasm in placental trophoblast cells, Hofbauer cells and placental vascular endothelial cells.
Conclusion:
The expression of DC-SIGNR in human placenta and trophoblast cells cultured in vitro is determined by IHC; The study provides a cellular basis for experiment in vitro aiming to investigate the mechanism of receptor-mediated intrauterine transmission.
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