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Updated: Jun 16, 2026

Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma
Published on: April 15, 2022
Myeloma cells with asurophilic granules--an unusual morphological variant--case presentation
Ana Maria Vlădăreanu1, Diana Cîşleanu, Mihaela Derveşteanu
1University of Medicine and Pharmacy Carol Davila, Clinic of Hematology Universitary Emergency Hospital, Bucharest.
Abstract:
We present the case of an 80-year-old man who was admitted for anemia, back pain and progressive weakness. After a workup of clinical and laboratory data, the final diagnosis was multiple myeloma. The bone marrow aspirate revealed 53% myeloma cells with peculiar and rare morphological features: numerous large asurophilic--bright red granules--mucopolizaccharides and immunoglobulins secreted and accumulated in the endoplasmic reticulum, typically known as Russel bodies.
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