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Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults

Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults

Published on: December 1, 2023

Modulating postoperative insulin resistance by preoperative carbohydrate loading.

Olle Ljungqvist¹

¹Karolinska Institutet, CLINTEC, Division of Surgery, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. olle.ljungqvist@ki.se

Best Practice & Research. Clinical Anaesthesiology

|January 30, 2010

Summary

Preoperative carbohydrate loading, instead of overnight fasting, offers significant clinical benefits by reducing postoperative insulin resistance. Updated guidelines now recommend this approach for elective surgery patients.

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Last Updated: Jun 16, 2026

Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults

Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults

Published on: December 1, 2023

Area of Science:

Anesthesiology and Perioperative Medicine
Metabolic and Endocrine Research

Background:

Traditional preoperative fasting guidelines are being re-evaluated.
Evidence suggests that overnight fasting offers no benefits over allowing clear fluids up to 2 hours before surgery.

Purpose of the Study:

To summarize the mechanisms and clinical effects of preoperative carbohydrate loading.
To provide an overview of current national guidelines recommending this practice.

Main Methods:

Review of existing evidence on preoperative carbohydrate loading.
Analysis of clinical benefits and underlying mechanisms, particularly reduced insulin resistance.
Summary of recent national guidelines on preoperative nutrition.

Main Results:

Preoperative carbohydrate loading, compared to overnight fasting, demonstrates significant clinical benefits.
Reduced postoperative insulin resistance is a key mechanism linked to carbohydrate loading.
Recent national guidelines recommend preoperative carbohydrates for elective major surgery.

Conclusions:

Preoperative carbohydrate loading is a beneficial strategy for patients undergoing elective surgery.
This approach enhances recovery by mitigating postoperative insulin resistance.
Updated guidelines support the integration of carbohydrate loading into preoperative fasting protocols.