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Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
Published on: November 28, 2015
Current data and strategy in glioblastoma multiforme.
Gabriel Iacob1, Eduard B Dinca
1Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. gbrl_cb@yahoo.com
Journal of Medicine and Life
|January 30, 2010
Summary
Glioblastoma multiforme (GBM) is an aggressive brain tumor resistant to therapy due to its heterogeneity. This review covers current GBM data, treatment strategies, and experimental approaches for both initial and recurrent disease.
Area of Science:
- Neuro-oncology
- Cancer biology
- Clinical neurology
Background:
- Glioblastoma multiforme (GBM), WHO grade IV, is the most common and aggressive primary brain tumor.
- GBM exhibits significant heterogeneity in clinical presentation, pathology, and genetics, contributing to therapeutic resistance.
Purpose of the Study:
- To present current data and treatment strategies for Glioblastoma multiforme.
- To discuss surgical, adjuvant, and experimental therapeutic approaches for GBM.
- To address the management of recurrent Glioblastoma multiforme.
Main Methods:
- Review of basic science data relevant to Glioblastoma.
- Analysis of key clinical aspects including surgery, radiotherapy, and chemotherapy.
- Discussion of experimental therapeutic approaches and recurrent GBM management.
Main Results:
- Glioblastoma's multiforme nature presents challenges in treatment.
- Current treatment strategies involve surgery, radiotherapy, and chemotherapy.
- Experimental approaches and management of recurrent GBM are critical areas of focus.
Conclusions:
- Effective Glioblastoma treatment requires understanding its heterogeneity.
- A multimodal approach combining surgery, adjuvant therapies, and novel strategies is essential.
- Further research into experimental therapies is crucial for improving outcomes in recurrent GBM.
