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Published on: July 12, 2018
[Study on viral pathogens for infant diarrhea in Chizhou, Anhui]
1People's Hospital of Chizhou, Anhui 247000, China.
Insights
Rotavirus is the primary viral cause of infant diarrhea in Chizhou, Anhui, followed by calicivirus and adenovirus. Type G3P8 rotavirus was the most common strain identified.
Area of Science:
- Virology
- Pediatrics
- Infectious Diseases
Context:
- Infant diarrhea poses a significant public health challenge globally.
- Understanding viral etiology is crucial for effective prevention and treatment strategies.
- Chizhou, Anhui, has specific epidemiological patterns of viral gastroenteritis.
Purpose:
- To identify the main viral pathogens responsible for infant diarrhea in Chizhou, Anhui.
- To characterize the prevalence and types of rotavirus, calicivirus, and adenovirus.
- To analyze seasonal trends of viral gastroenteritis in infants.
Summary:
- Rotavirus was detected in 29.2% of cases, followed by calicivirus (10.5%) and adenovirus (2.4%).
- Rotavirus serotype G3, particularly G3P8, was the predominant strain, with a high prevalence during winter and spring.
- Calicivirus prevalence peaked in the fall.
Impact:
- This study highlights rotavirus as the leading viral agent of infant diarrhea in the region.
- Findings inform targeted public health interventions and vaccination programs.
- Data contributes to the broader understanding of viral gastroenteritis epidemiology in China.
Objective:
To understand the major viral pathogens for infant diarrhea in Chizhou, Anhui.
Methods:
Fecal specimens were collected from 428 infants hospitalized with diarrhea in People's Hospital of Chizhou, Anhui between January 2005 and December 2006. Enzyme immunoassay (EIA) and enzyme-linked immunosorbent assay (ELISA) were performed to detected specific antigens of rotavirus, astrovirus, adenovirus or calicivirus. For rotavirus, specimens were tested for typing by serum virology and reverse transcription PCR (RT-PCR).
Results:
The positive test rates for rotavirus, calicivirus and adenovirus were 29.2%, 10.5% and 2.4%, respectively, in infants with diarrhea from Chizhou, Anhui. Among them, 3 cases (2.4%) were infected with two or more viruses. Forty-four fecal specimens were tested with ELISA and RT-PCR for rotavirus, and the results showed that the two methods got consistency of 97.7%. Another 48 rotaviruses of serotype G were further typed as serotype I (3 cases), II (1 case), III (35 cases) and IX (2 cases), with 7 cases untyped. Among the cases that could be typed, 26 cases were collected from 2005, and 15 from 2006. RV type ml was the major pathogens for infant diarrhea, with 24 from 2005 and 11 from 2006. Among the 8 rotaviruses of type P, 7 were type as G3P8 and one G9P8. The epidemic of rotavirus showed significant season privilege, with a high prevalence in winter-spring, while the prevalence of calicivirus was prone to be high in Fall.
Conclusion:
Rotavirus was the major viral pathogen accounting for infant diarrhea in Chizhou, Anhui, followed by calicivirus and adenovirus Type G3 was the main rotavirus, especially type G3P8.
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