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Published on: August 1, 2013
Development of enterovirus 71 vaccines
1Vaccine Research and Development Center, National Health Research Institutes, Taiwan. minshi@nhri.org.tw
Expert Review of Vaccines
|January 30, 2010
Summary
Enterovirus 71 (EV71) causes severe neurological issues and is a prime target for vaccine development. Inactivated whole-virus vaccines show promise for upcoming clinical trials.
Area of Science:
- Virology
- Epidemiology
- Vaccinology
Background:
- Enterovirus 71 (EV71), first isolated in 1969, has caused significant epidemic outbreaks globally.
- EV71 infection can lead to severe central nervous system (CNS) involvement, resulting in neurological sequelae, developmental delays, and cognitive impairment.
- With poliovirus near eradication, EV71 is a leading candidate for novel enterovirus vaccine development.
Purpose of the Study:
- To review the current landscape of EV71 vaccine candidates.
- To identify promising vaccine platforms for clinical development.
- To highlight the potential of inactivated whole-virus vaccines for EV71.
Main Methods:
- Review of existing literature on EV71 vaccine research.
- Analysis of various vaccine platforms including live-attenuated, inactivated, recombinant protein, virus-like particle, and DNA vaccines.
- Evaluation of animal study data and historical poliovirus vaccine experiences.
Main Results:
- Several EV71 vaccine candidates have undergone animal evaluation.
- No clinical trials for EV71 vaccines have been initiated to date.
- Inactivated whole-virus vaccines are considered feasible and likely candidates for rapid clinical trial preparation.
Conclusions:
- EV71 remains a significant public health threat necessitating vaccine intervention.
- Inactivated whole-virus vaccines represent a practical and potentially licensable approach for EV71 prevention.
- Clinical trials focusing on inactivated EV71 vaccines are being prepared, particularly in Asia.
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