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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Development of a database and ontology for pathogenic pathways in periodontitis
Asami Suzuki1, Takako Takai-Igarashi, Yukihiro Numabe
1General Dentistry, The Nippon Dental University Hospital at Tokyo, Tokyo, Japan.
In Silico Biology
|January 30, 2010
Summary
This study introduces a new database detailing molecular pathways in periodontitis, a gum disease linked to cardiovascular issues. The database systematizes pathway information to better understand periodontitis pathology.
Area of Science:
- Molecular Biology
- Bioinformatics
- Pathology
Background:
- Pathway information is crucial for understanding the molecular basis of human diseases using large-scale biological data.
- Periodontitis, an inflammation of periodontal tissue, is linked to increased risks of cardiovascular events like angina and myocardial infarction.
- Despite extensive research, a systematic compilation of biological pathways involved in periodontitis pathology is lacking.
Purpose of the Study:
- To develop a comprehensive pathway database for the molecular pathology of periodontitis.
- To systematize and integrate existing knowledge on molecular pathways and causal relationships in periodontitis.
- To provide a resource for understanding the cellular and tissue-specific aspects of periodontitis pathology.
Main Methods:
- Reviewed 185 reference papers to extract molecular causal relationships and pathways relevant to periodontitis.
- Developed a structured ontology to systematize conceptual terms associated with identified pathways.
- Integrated cellular and tissue-specific contextual information into the ontology.
- Implemented an integrated viewer for exploring associations between pathways and ontological terms.
Main Results:
- Created the 'Pathogenic Pathway Database for Periodontitis', a novel resource for molecular pathology.
- Extracted and organized causal relationships and pathways from extensive literature review.
- Developed an ontology that includes pathway, cellular, and tissue-specific information.
- Implemented an integrated viewer for intuitive data exploration.
Conclusions:
- The 'Pathogenic Pathway Database for Periodontitis' provides a systematized resource for understanding periodontitis molecular pathology.
- The integrated pathway and ontology information aids in elucidating the molecular etiology of periodontitis and its systemic associations.
- This database serves as a valuable tool for researchers investigating periodontitis and related diseases.
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