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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...

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Related Experiment Video

Updated: Jun 16, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

[Lichen sclerosus].

V Monsálvez1, R Rivera, F Vanaclocha

  • 1Servicio de Dermatología, Hospital 12 de Octubre, Madrid, España. monsalvezhonrubia@hotmail.com

Actas Dermo-Sifiliograficas
|January 30, 2010
PubMed
Summary
This summary is machine-generated.

Lichen sclerosus is a chronic inflammatory skin condition affecting all ages. Potent topical corticosteroids are the primary treatment, with surgery reserved for severe complications.

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Area of Science:

  • Dermatology
  • Immunology
  • Genetics

Context:

  • Lichen sclerosus is a chronic inflammatory mucocutaneous disease impacting quality of life across all age groups.
  • The precise causes of lichen sclerosus remain unclear, with potential links to genetic predisposition, autoimmune responses, and infectious agents.

Purpose:

  • To summarize the current understanding of lichen sclerosus etiology and management.
  • To outline the established first-line and surgical treatment options for lichen sclerosus.

Summary:

  • First-line management involves short-term application of high-potency topical corticosteroids.
  • Surgical intervention is indicated for specific complications such as phimosis, urethral stenosis, synechiae, and the development of squamous cell carcinoma.

Impact:

  • Provides a concise overview of lichen sclerosus for clinicians and researchers.
  • Highlights the importance of timely and appropriate treatment for managing this condition and its sequelae.