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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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Left ventricular noncompaction.

Radha J Sarma1, Amar Chana, Uri Elkayam

  • 1ABIM, Internal Medicine and Cardiovascular Diseases, University of Southern California, Keck School of Medicine, Division of Cardiovascular Medicine, Los Angeles, CA 90033, USA. sarma@usc.edu

Progress in Cardiovascular Diseases
|January 30, 2010
PubMed
Summary
This summary is machine-generated.

Left ventricular noncompaction, an unclassified cardiomyopathy, lacks diagnostic consensus. Current research reviews its diagnosis, prognosis, and management in adults, suggesting a better outlook than previously thought.

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Area of Science:

  • Cardiology
  • Genetics
  • Medical Diagnostics

Background:

  • Left ventricular noncompaction (LVNC) remains unclassified by the World Health Organization.
  • Classified as a primary genetic cardiomyopathy by the American Heart Association in 2006.
  • European Society of Cardiology's 2008 classification aligns with WHO, highlighting ongoing classification challenges.

Purpose of the Study:

  • To review the current status of diagnosis, prognosis, and management of isolated left ventricular noncompaction in adults.
  • To address the lack of consensus on diagnostic criteria and standardization.
  • To improve awareness and understanding of this condition among clinicians.

Main Methods:

  • Review of existing literature on left ventricular noncompaction.
  • Analysis of diagnostic criteria based on cardiac imaging and autopsy findings.
  • Evaluation of reported prognosis and therapeutic approaches.

Main Results:

  • Diagnosis relies on morphologic features from cardiac imaging or autopsy due to lack of standardized criteria.
  • The true prevalence of left ventricular noncompaction is unclear owing to diagnostic inconsistencies and limited clinician awareness.
  • Prognosis appears to be more favorable than initially reported.

Conclusions:

  • There is a critical need for consensus on diagnostic criteria for left ventricular noncompaction.
  • Increased clinician awareness and standardized diagnostic approaches are essential.
  • Despite challenges, the prognosis for isolated noncompaction in adults may be better than previously understood.