Related Experiment Video

Updated: Jun 16, 2026

Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction
08:31

Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction

Published on: July 26, 2018

Amyloid heart disease

Rodney H Falk1, Simon W Dubrey

  • 1Harvard Vanguard Medical Associates, Harvard Medical School, Boston, MA 02215, USA. rfalk@partners.org

Progress in Cardiovascular Diseases
|January 30, 2010
PubMed

Insights

Systemic amyloidoses involve amyloid deposition in organs, often affecting the heart and causing cardiomyopathy. Accurate diagnosis and biochemical typing are crucial for effective treatment and improved prognosis.

Area of Science:

  • Cardiology
  • Hematology
  • Pathology

Background:

  • Systemic amyloidoses are rare disorders with amyloid deposition in organs.
  • Cardiac involvement is frequent, manifesting as infiltrative/restrictive cardiomyopathy.
  • Cardiac amyloidosis can be the initial presentation or found during non-cardiac investigations.

Purpose of the Study:

  • To review the diverse features and manifestations of cardiac amyloidosis.
  • To emphasize the importance of early suspicion and accurate diagnosis.
  • To highlight the impact of recent therapeutic advancements.

Main Methods:

  • Review of clinical features and diagnostic approaches for cardiac amyloidosis.
  • Discussion of biochemical typing of amyloid deposits.
  • Analysis of treatment strategies and prognostic implications.

Main Results:

  • Cardiac amyloidosis presents with varied clinical manifestations.
  • Accurate biochemical typing of amyloid is essential for targeted therapy.
  • Timely and appropriate treatment significantly improves patient outcomes.

Conclusions:

  • Cardiac amyloidosis requires a high index of suspicion for timely diagnosis.
  • Precise biochemical typing guides therapeutic decisions.
  • Advances in therapy offer improved prognosis for systemic amyloidoses with cardiac involvement.

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