Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cellular Adaptation IV: Dysplasia and Metaplasia01:24

Cellular Adaptation IV: Dysplasia and Metaplasia

DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Cellular Adaptation III: Hyperplasia01:26

Cellular Adaptation III: Hyperplasia

Hyperplasia is an increase in the number of cells in a tissue or organ due to enhanced cell division. It is an adaptive, controlled response to stimuli such as injury, hormones, or stress, involving mitosis to produce genetically identical cells and support tissue repair and regeneration.Tissue CapacityCertain tissues, including the epidermis, intestinal epithelium, bone marrow, and fibroblasts, have a high potential for hyperplasia. Others, such as bone, cartilage, and smooth muscle, show...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient-derived organoids across cancers reveal conserved tumor heterogeneity and actionable therapeutic vulnerabilities.

Science advances·2026
Same author

Targeting Ferroptosis to Overcome Radioresistance and Enhance Immunotherapy in Colorectal Cancer.

Cells·2026
Same author

Instability in Pentanucleotide Markers in a Subset of Microsatellite Instability-High Colorectal Cancer.

Current oncology (Toronto, Ont.)·2026
Same author

The Need for Individualized Decision-Making for Neoadjuvant Therapy in Advanced Colon Cancer.

JAMA surgery·2026
Same author

A history of the collaborative group of the Americas on inherited gastrointestinal cancer (CGA-IGC): 1995-2025.

Familial cancer·2026
Same author

A Critical Appraisal of Colorectal Surgery Fellowship Standardized Letters of Recommendations Using Objective Criteria.

Diseases of the colon and rectum·2026
Same journal

Social Determinants of Health, Health Disparities, and Surgical Equity.

The Surgical clinics of North America·2026
Same journal

Beyond the Scalpel's Reach.

The Surgical clinics of North America·2026
Same journal

Stepwise Solutions-Society.

The Surgical clinics of North America·2026
Same journal

Stepwise Solutions-Hospitals.

The Surgical clinics of North America·2026
Same journal

Stepwise Solutions for Providers.

The Surgical clinics of North America·2026
Same journal

Stepwise Solutions-Patients Social Determinants of Health, Health Disparities, and Surgical Equity.

The Surgical clinics of North America·2026
See all related articles

Related Experiment Video

Updated: Jun 16, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Anal neoplasms.

Kelly Garrett1, Matthew F Kalady

  • 1Department of Colorectal Surgery, Digestive Disease Institute, 9500 Euclid Avenue, A30 Cleveland Clinic, Cleveland, OH 44195, USA.

The Surgical Clinics of North America
|January 30, 2010
PubMed
Summary
This summary is machine-generated.

Anal canal tumors vary, with carcinoma in situ and epidermoid cancers most common. This review details various anal neoplasms and their management, including local excision for rectal cancer.

Related Experiment Videos

Last Updated: Jun 16, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Area of Science:

  • Oncology
  • Gastroenterology
  • Surgical Pathology

Background:

  • The anal canal harbors diverse neoplastic lesions.
  • Carcinoma in situ and epidermoid cancers represent the most frequent malignancies.
  • Less common tumors include adenocarcinoma, melanoma, GISTs, NETs, and Buschke-Lowenstein tumors.

Purpose of the Study:

  • To comprehensively review the spectrum of anal canal tumors.
  • To delineate the distinct histopathological types and their characteristics.
  • To discuss current management strategies tailored to tumor type and location.

Main Methods:

  • Literature review of anal canal neoplasms.
  • Analysis of treatment modalities based on histopathology and anatomical site.
  • Inclusion of a brief overview of local excision for rectal cancer.

Main Results:

  • Identification of common (carcinoma in situ, epidermoid) and rare anal tumors.
  • Correlation of treatment approaches with specific tumor types and locations.
  • Emphasis on tailored management strategies for optimal patient outcomes.

Conclusions:

  • Effective management of anal tumors requires accurate histopathological diagnosis.
  • Treatment strategies must be individualized based on tumor characteristics and location.
  • Understanding the diverse nature of anal neoplasms is crucial for effective clinical practice.