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Updated: Jun 16, 2026

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

Principles of antimicrobial therapy.

Jeffrey M Tessier¹, W Michael Scheld

¹Virginia Commonwealth University, Richmond, 23298-0049, USA. jmtessier@vcu.edu

Handbook of Clinical Neurology

|January 30, 2010

Summary

This summary is machine-generated.

Choosing effective antimicrobial treatments for bacterial meningitis and brain abscess involves selecting bactericidal drugs that cross the blood-brain barrier. Tailor therapy based on pathogen and clinical response, ensuring adequate duration for CNS infections.

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Area of Science:

Neuroscience
Infectious Diseases
Pharmacology

Background:

Central nervous system (CNS) infections like bacterial meningitis and brain abscess require careful antimicrobial selection.
Optimal antimicrobial therapy principles for these conditions may extend to other CNS infections.
Limited pharmacological data exists for non-bacterial CNS infections.

Purpose of the Study:

To discuss key factors in selecting antimicrobial regimens for bacterial meningitis and brain abscess.
To highlight common themes in treating CNS infections.
To provide guidance on antimicrobial therapy based on current understanding.

Main Methods:

Review of pharmacological and microbiological aspects of antimicrobial therapy for CNS infections.
Emphasis on studies in experimental animal models and human data.
Summary of current understanding of appropriate antimicrobial therapy.

Main Results:

Bactericidal antimicrobials crossing the blood-brain barrier (BBB) are crucial for achieving high cerebrospinal fluid (CSF) concentrations.
Pharmacodynamic (PD) parameters like time above minimum bactericidal concentration (MBC) are important.
Tailoring therapy based on microbiological data, including consideration for anaerobes in brain abscess, is recommended.

Conclusions:

Bacterial meningitis treatment duration varies: 7-10 days for non-meningococcal, 3-4 days for meningococcal, guided by clinical response.
Brain abscess treatment requires at least 6 weeks of intravenous antimicrobials post-drainage, monitored by clinical and radiographic improvement.
Effective antimicrobial therapy for CNS infections necessitates careful drug selection, consideration of PD, and tailored treatment duration.