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Updated: Jun 16, 2026

Murine Model of Epicutaneously-Induced Immunomodulation
Published on: June 24, 2025
Recent insights into atopic dermatitis and implications for management of infectious complications
Mark Boguniewicz1, Donald Y M Leung
1Division of Pediatric Allergy-Immunology, Department of Pediatrics, National Jewish Health and University of Colorado School of Medicine, 1400 Jackson St, Rm J310, Denver, CO 80206, USA. boguniewiczm@njhealth.org
Abstract:
Atopic dermatitis (AD) is a common complex disease that frequently follows a chronic relapsing course and affects the quality of life of patients and families in a significant manner. New insights into the pathophysiology of AD point to an important role of structural abnormalities in the epidermis combined with immune dysregulation. Patients with AD have a unique predisposition to colonization or infection by a number of microbial organisms, most notably Staphylococcus aureus and herpes simplex virus. A multipronged approach directed at healing or protecting the skin barrier and addressing the immune dysregulation is necessary to improve the likelihood of successful outcomes.
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