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Updated: Jun 16, 2026

Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit
Published on: June 28, 2013
Development of Chemical Bond based Elastic Network Model and its application in identifying functional motions in
1Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA. jang.yunho@gmail.com
Abstract:
Here we proposed a Chemical Bond based Elastic Network Model (CB-ENM) method, which was demonstrated with a better performance in representing functional movements, especially the local motions, than the conventional normal mode analysis. CB-ENM was applied in characterising functional motions in surface glycoprotein Haemagglutinin (HA) of H5N1 highly pathogenic avian influenza virus. Eleven local peaks were identified amongst HA fluctuation spectrum, and eight of these peaks were correlated with the reported five antigenic binding sites and Receptor Binding Sites (RBS) in influenza viruses. Our study showed that CB-ENM has a potential in identifying functional residues in protein structure.
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