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Updated: Jun 16, 2026

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
Published on: September 16, 2017
Multiple inflow pulsed arterial spin-labeling reveals delays in the arterial arrival time in minor stroke and
B J MacIntosh1, A C Lindsay, I Kylintireas
1Department of Clinical Neurology, University of Oxford, Oxfordshire, United Kingdom. bmac@fmrib.ox.ac.uk
Abstract:
Our purpose was to use multiple inflow pulsed ASL to investigate whether hemodynamic AAT information is sensitive to hemispheric asymmetry in acute ischemia. The cohorts included 15 patients with acute minor stroke or TIA and 15 age-matched controls. Patients were scanned by using a stroke MR imaging protocol at a median time of 74 hours. DWI lesion volumes were small and functional impairment was low; however, perfusion abnormalities were evident. Prolonged AAT values were more likely to reside in the affected hemisphere (significant when compared with controls, P < .048). An advantage of this ASL technique is the ability to use AAT information in addition to CBF to characterize ischemia.
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