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A novel mesoporous biomaterial for treating dentin hypersensitivity.

Y-C Chiang1, H-J Chen, H-C Liu

  • 1School of Dentistry and Graduate Institute of Clinical Dentistry, National Taiwan University and National Taiwan University Hospital, No. 1, Chang-Te Street, Taipei 10016, Taiwan.

Journal of Dental Research
|January 30, 2010
PubMed
Summary

A novel nano CaO@mesoporous silica (NCMS) biomaterial effectively occludes dentinal tubules, significantly reducing dentin hypersensitivity and permeability, even under pulpal pressure.

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Area of Science:

  • Biomaterials Science
  • Dental Research
  • Nanotechnology

Background:

  • Dentin hypersensitivity remains a clinical challenge, with no ideal treatment available.
  • Calcium phosphate precipitation shows promise for occluding dentinal tubules.
  • Mesoporous silica biomaterials offer potential for enhanced therapeutic delivery.

Purpose of the Study:

  • To investigate the efficacy of a novel mesoporous silica biomaterial (nano CaO@mesoporous silica, NCMS) for treating dentin hypersensitivity.
  • To evaluate the ability of NCMS to occlude dentinal tubules and reduce dentin permeability under pulpal pressure.
  • To compare the performance of NCMS with existing dental desensitizing materials.

Main Methods:

  • A novel NCMS paste containing nano-sized calcium oxide particles and phosphoric acid was prepared.

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  • The NCMS paste was applied to dentin surfaces.
  • Dentin permeability was measured under simulated pulpal pressure and compared to controls.

    • Main Results:

    • NCMS paste facilitated deep diffusion of Ca(2+) and HPO(4)(2-) ions into dentinal tubules.
    • A significant precipitation of CaHPO(4).2H(2)O was formed, occluding tubules to a depth of 100 microm.
    • NCMS demonstrated a significant reduction in dentin permeability (p < 0.05) compared to DP-bioglass and Seal & Protect, even under pulpal pressure.

    Conclusions:

    • The novel NCMS biomaterial effectively occludes dentinal tubules and reduces dentin permeability.
    • NCMS shows superior performance in reducing dentin permeability compared to existing materials, particularly under pulpal pressure.
    • NCMS represents a promising new biomaterial for the treatment of dentin hypersensitivity.