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Related Experiment Video

Updated: Jun 16, 2026

Transcranial Direct Current Stimulation (tDCS) for Memory Enhancement

Transcranial Direct Current Stimulation (tDCS) for Memory Enhancement

Published on: September 18, 2021

Complex antioxidant blend improves memory in community-dwelling seniors.

William K Summers¹, Roy L Martin, Michael Cunningham

¹Alzheimer's Corporation, Albuquerque, NM, USA.

Journal of Alzheimer'S Disease : JAD

|January 30, 2010

Summary

A four-month antioxidant blend improved memory in older adults without dementia. The supplement also significantly reduced homocysteine levels, a marker associated with cognitive decline.

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Last Updated: Jun 16, 2026

Transcranial Direct Current Stimulation (tDCS) for Memory Enhancement

Transcranial Direct Current Stimulation (tDCS) for Memory Enhancement

Published on: September 18, 2021

Area of Science:

Gerontology
Neuroscience
Nutritional Science

Background:

Cognitive decline is a growing concern in aging populations.
Homocysteine levels are linked to cognitive function and dementia risk.
Antioxidants play a role in cellular protection and may influence brain health.

Purpose of the Study:

To investigate the effects of a complex antioxidant blend on memory performance in healthy older adults.
To assess the impact of the antioxidant blend on serum homocysteine levels.

Main Methods:

A randomized, double-blind, placebo-controlled trial was conducted.
113 community-dwelling adults aged 50-75 without dementia were recruited.
Participants received either a complex antioxidant blend or a placebo for four months.
Memory was assessed using paired association and immediate recall tests.
Serum homocysteine levels were measured as a secondary outcome.

Main Results:

Significant improvements were observed in both paired association (p=0.015) and immediate recall (p=0.005) memory tests in the active treatment group.
The active treatment group showed a significant reduction in serum homocysteine levels (p=0.005).

Conclusions:

A four-month course of a complex antioxidant blend can enhance memory function in elderly individuals.
The antioxidant blend effectively reduces serum homocysteine levels in this population.
These findings suggest a potential role for antioxidants in supporting cognitive health in aging.