Related Experiment Video
Updated: Jun 16, 2026
08:34
Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
Published on: July 27, 2022
Ileocolonic involvement in Behçet's disease: endoscopic and histological evaluation
Seyfettin Köklü1, Osman Yüksel, Ilknur Onur
1Department of Gastroenterology, Ankara Education and Research Hospital, Ankara, Turkey. gskoklu@yahoo.com
Digestion
|January 30, 2010
Summary
Gastrointestinal involvement, particularly in the ileum, is common in Behçet's disease (BD), even without visible endoscopic lesions. Microscopic analysis reveals frequent inflammation in the lower GI tract of BD patients.
Area of Science:
- Gastroenterology
- Rheumatology
- Internal Medicine
Background:
- Behçet's disease (BD) is a multisystemic inflammatory disorder.
- Gastrointestinal (GI) involvement is a recognized but variably reported manifestation of BD.
- Endoscopic evaluation is crucial for diagnosing GI involvement in BD.
Purpose of the Study:
- To determine the frequency of GI involvement in Behçet's disease using endoscopic examination.
- To investigate the correlation between GI lesions and other systemic manifestations of BD.
Main Methods:
- Fifty patients diagnosed with Behçet's disease underwent colonoscopy, including terminal ileum examination and biopsy.
- Upper GI endoscopy was performed, and clinical data on systemic involvement were collected.
- A control group of 30 healthy individuals underwent colonoscopy for comparison.
Main Results:
- Macroscopic lesions were observed in the ileum of 9 patients and the colon in 1 patient.
- Microscopic examination revealed abnormal ileum histology in 61% of BD patients versus 30% in controls (p < 0.001).
- No correlation was found between GI involvement (macro- or microscopic) and other systemic components of BD.
Conclusions:
- Lower GI tract involvement, especially the ileum, is a frequent finding in Behçet's disease.
- Ileal inflammation is common in BD patients, often present even when endoscopic findings are normal.
- Endoscopic and histological evaluation is important for detecting GI involvement in BD.
Related Concept Videos
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:26Inflammatory Bowel Disease I: Introduction
Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
01:20Inflammatory Bowel Disease II: Ulcerative Colitis
Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
01:25Endoscopic Procedures II: Colonoscopy
The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
01:17Chronic Bowel Disorders: Introduction
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...