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Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
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Response to the Letter to the Editor Entitled "Integrating Tissue Proteomics and Urinary Analysis to Capture Dynamic Podocyte Injury".

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Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
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Membranous glomerulopathy: the evolving story.

Pierre Ronco1, Hanna Debiec

  • 1INSERM UMR_S 702, Paris, France. pierre.ronco@tnn.aphp.fr

Current Opinion in Nephrology and Hypertension
|January 30, 2010
PubMed
Summary
This summary is machine-generated.

New research identifies key antigens, neutral endopeptidase (NEP) and phospholipase A2 receptor (PLA2R), in membranous nephropathy. These discoveries offer new diagnostic tools and pave the way for targeted therapies for this common kidney disease.

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Last Updated: Jun 16, 2026

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

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Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
06:39

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Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins
09:12

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins

Published on: January 18, 2019

Area of Science:

  • Nephrology
  • Immunology
  • Pathophysiology

Background:

  • Membranous nephropathy is a leading cause of glomerulopathy.
  • Current treatments are empirical, lacking pathophysiology-driven approaches.
  • Understanding disease mechanisms requires identifying antigenic targets.

Purpose of the Study:

  • To review new pathophysiologic aspects of membranous nephropathy.
  • To focus on the antigenic targets of pathogenic antibodies in membranous nephropathy.
  • To highlight recent discoveries in the field.

Main Methods:

  • Literature review of recent findings in membranous nephropathy.
  • Analysis of identified antigenic targets.
  • Discussion of implications for diagnosis and therapy.

Main Results:

  • Two major antigens identified: neutral endopeptidase (NEP) and M-type phospholipase A2 receptor (PLA2R).
  • NEP is implicated in neonatal membranous nephropathy.
  • PLA2R is the first identified autoantigen in adult idiopathic membranous nephropathy.

Conclusions:

  • Podocyte expression of antigenic targets is common in membranous nephropathy.
  • NEP and PLA2R discoveries provide tools for monitoring disease activity.
  • These findings are valuable for developing new antigen-driven therapeutic strategies.