Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nucleosome Remodeling02:54

Nucleosome Remodeling

8.8K
Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
8.8K
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

8.1K
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
8.1K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

6.0K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
6.0K
Duplication of Chromatin Structure02:05

Duplication of Chromatin Structure

6.1K
The process of chromosome duplication during cell division requires genome-wide disruption and re-assembly of chromatin. The chromatin structure must be accurately inherited, reassembled, and maintained in the daughter cells to ensure lineage propagation.
The basic unit of the chromatin is the nucleosome, consisting of DNA wrapped around octameric histone proteins and short stretches of linker DNA separating individual nucleosomes. The histone proteins within the nucleosome have their...
6.1K
Heterochromatin02:38

Heterochromatin

12.0K
The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions that take up more dye are called heterochromatin. Heterochromatin is further classified into two forms – constitutive heterochromatin and facultative heterochromatin.
Constitutive heterochromatin: It is a highly compact region of chromatin that is mostly concentrated in the centromere and telomere. Unlike euchromatin, the amino acid at...
12.0K
Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

1.5K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Loss of STMP1 Perturbs Mitochondrial Cristae and Drives Cellular Inflammation and Heart Failure.

Circulation·2026
Same author

Design and Development of DNA Damage Chemical Inducers of Proximity for Targeted Cancer Therapy.

Journal of the American Chemical Society·2026
Same author

Design and Development of DNA Damage Chemical Inducers of Proximity (DD-CIP) for Targeted Cancer Therapy.

bioRxiv : the preprint server for biology·2025
Same author

Elucidating the Localization and Interactome of Mitochondrial Microproteins.

Methods in molecular biology (Clifton, N.J.)·2025
Same author

Remote spatial memory deficits in mouse models of neuropsychiatric disorders with immature dentate gyrus phenotype.

The international journal of neuropsychopharmacology·2025
Same author

Microprotein SMIM26 drives oxidative metabolism via serine-responsive mitochondrial translation.

Molecular cell·2025
Same journal

Daily briefing: 'Cyborg' cockroaches breathe underwater with printed suit.

Nature·2026
Same journal

China boosts prestigious grants for young scientists - will it ease competition?

Nature·2026
Same journal

Incoming US science academy chief vows to 'double down' on research.

Nature·2026
Same journal

Author Correction: Synthesis of enantioenriched atropisomers by biocatalytic deracemization.

Nature·2026
Same journal

Electrodeposited self-assembled molecules for perovskite photovoltaics.

Nature·2026
Same journal

Neutrino's nursery found: the 'Shadow Blaster'.

Nature·2026
See all related articles

Related Experiment Video

Updated: May 5, 2026

Chromatin Immunoprecipitation ChIP in Mouse T-cell Lines
11:39

Chromatin Immunoprecipitation ChIP in Mouse T-cell Lines

Published on: June 17, 2017

19.6K

Chromatin remodelling during development.

Lena Ho1, Gerald R Crabtree

  • 1Stanford University Medical School, Room B211, Beckman Center, 279 Campus Drive, Stanford, California 94305, USA.

Nature
|January 30, 2010
PubMed
Summary
This summary is machine-generated.

New research reveals that ATP-dependent chromatin remodeling enzymes play crucial roles in cell development. These enzymes are essential for maintaining cell pluripotency and multipotency, offering insights into developmental mechanisms.

More Related Videos

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
10:09

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Published on: January 26, 2018

6.8K
Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

6.1K

Related Experiment Videos

Last Updated: May 5, 2026

Chromatin Immunoprecipitation ChIP in Mouse T-cell Lines
11:39

Chromatin Immunoprecipitation ChIP in Mouse T-cell Lines

Published on: June 17, 2017

19.6K
Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
10:09

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Published on: January 26, 2018

6.8K
Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

6.1K

Area of Science:

  • Molecular Biology
  • Genetics
  • Developmental Biology

Background:

  • Chromatin structure is dynamic and undergoes significant changes during development.
  • Histone modifications and DNA methylation are key regulators of chromatin.
  • ATP-dependent chromatin remodeling enzymes are crucial for controlling chromatin structure.

Purpose of the Study:

  • To explore the roles of ATP-dependent chromatin remodeling enzymes in development.
  • To understand the mechanisms by which these enzymes influence cell states.

Main Methods:

  • Genome-wide analysis of chromatin.
  • Studies on histone modifications.
  • Investigation of ATP-dependent chromatin remodeling enzymes.

Main Results:

  • Chromatin structure and histone modifications change globally during development.
  • ATP-dependent chromatin remodelers are major contributors to chromatin dynamics.
  • Specialized assemblies of these remodelers are vital for cell pluripotency and multipotency.

Conclusions:

  • Chromatin remodeling enzymes have instructive and programmatic roles in development.
  • These enzymes are essential for establishing and maintaining pluripotent and multipotent cell states.