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The unusually high immunomodulatory activity of thymopentin analogue Pro5-TP-5
Z Wieczorek1, W Voelter, E Nawrocka-Bolewska
1Institute of Immunology and Experimental Therapy, Wroclaw, Poland.
Molecular Immunology
|January 1, 1991
Abstract:
The immunomodulatory potency of a series of proline-containing thymopentin (TP-5) analogues was investigated by PFC (in vitro and in vivo) test and by GvH reaction. It was found that the substitution of Asp in position 3 of TP-5 by D-Pro yields a distinctly more active compound than that obtained by substitution of Asp3 by L-Pro. Pro5-TP-5 showed very strongly enhanced activity as compared with TP-5; the effect is especially well obvious in PFC in vitro (15-fold enhancement of activity).