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Published on: August 18, 2017
Fluorine & chirality: how to create a nonracemic stereogenic carbon-fluorine centre?
Dominique Cahard1, Xiuhua Xu, Samuel Couve-Bonnaire
1UMR CNRS 6014 C.O.B.R.A., Université et INSA de Rouen, rue Tesnière, 76130 Mont Saint Aignan, France. dominique.cahard@univ-rouen.fr
Abstract:
Enantiopure organofluorine compounds are at the forefront of innovation in the field of fluorine chemistry. The significant progress in modern fluoroorganic chemistry parallels the tremendous achievements in organocatalysis and organometallic catalysis that have permitted the asymmetric synthesis of chiral chemicals featuring a fluorinated stereogenic carbon centre. This tutorial review provides an overview of the current state of the art in asymmetric construction of stereogenic carbon-fluorine centres, not only by direct fluorination, but also by asymmetric reaction of fluorinated substrates.
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