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Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

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Published on: January 9, 2019

Polymorphous lymphoproliferative disorder: a clinicopathological analysis.

Naoto Nakamichi¹, Naoki Wada, Masaharu Kohara

¹Department of Pathology (C3), Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Virchows Archiv : an International Journal of Pathology

|January 30, 2010

Summary

Polymorphous lymphoproliferative disorder (LPD) is a rare, heterogeneous condition. This study found it often involves monoclonal B or T cell proliferation, can be EBV-associated, and typically presents as an aggressive lymphoma.

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Area of Science:

Hematology
Oncology
Immunology

Background:

Polymorphous lymphoproliferative disorder (LPD) is characterized by a mixed cellular composition, often seen in immunodeficient individuals.
This study investigates clinicopathological features of polymorphous LPD in Japan.

Purpose of the Study:

To analyze the clinicopathological findings, clonality, Epstein-Barr virus (EBV) association, and prognosis of polymorphous LPD.

Main Methods:

Analysis of 19 cases of polymorphous LPD.
Southern blotting and/or polymerase chain reaction (PCR) for clonality assessment.
EBV detection.

Main Results:

Polymorphous LPD represented 0.4% of registered cases, with six cases having a history of rheumatoid arthritis and immunosuppressive agent use.
Monoclonal B-cell proliferation (B-LPD) and T-cell proliferation (T-LPD) were identified in 8 and 6 cases, respectively.
EBV was detected in some B-LPD, T-LPD, and polyclonal LPD cases. The 3-year overall survival rate was 49.7%.

Conclusions:

Polymorphous LPD is a rare, heterogeneous disease in Japan, often exhibiting monoclonal B or T cell proliferation.
The condition is occasionally EBV-associated and behaves aggressively, with a poor prognosis.
Further research is needed to understand its diverse origins and optimize treatment strategies.