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Lapachol induces clastogenic effects in rats.

Edson Luis Maistro1, Diego Mota Fernandes, Fernanda Maria Pereira

  • 1Departamento de Fonoaudiologia, Faculdade de Filosofia e Ciências, Universidade Estadual Paulista (UNESP), Marília, São Paulo, Brazil. edson.maistro@marilia.unesp.br

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|January 30, 2010
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Summary

Lapachol, a plant-derived compound, was tested for mutagenicity in rats. High doses of lapachol induced genetic damage in bone marrow cells, indicating potential clastogenic effects.

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Area of Science:

  • Natural Products Chemistry
  • Toxicology
  • Genetics

Background:

  • Lapachol is a naphthoquinone derivative from Tabebuia plants.
  • It possesses various therapeutic properties but lacks in vivo mutagenicity data.

Purpose of the Study:

  • To investigate the in vivo mutagenic potential of lapachol.
  • To assess lapachol's effects in micronucleus and chromosome aberration assays.

Main Methods:

  • Oral administration of lapachol (122, 244, 365 mg/kg) to male Wistar rats.
  • Analysis of bone marrow cells for micronucleated polychromatic erythrocytes (MNPCE) and chromosome aberrations (CAs).

Main Results:

  • A significant increase in MNPCE frequency was observed at the highest lapachol dose.
  • Lapachol induced a significant increase in chromosome aberrations at the highest dose.

Conclusions:

  • Lapachol exhibits clastogenic effects in vivo at the tested doses.
  • Further investigation into lapachol's genotoxicity is warranted.