Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Degeneration-Inspired Architectural States Defined by Voronoi Point Spacing and Surface-Mediated Rescue of Osteogenic Dysfunction in 3D-Printed Scaffolds.

bioRxiv : the preprint server for biology·2026
Same author

Plasma-Enabled Multiscale Coupling of Architecture and Biointerfaces Drives Osteogenesis in 3D-Printed Gyroid Scaffolds.

bioRxiv : the preprint server for biology·2026
Same author

Caveolin in extracellular vesicles: orchestrating interorgan communication in diabetes-associated cardiovascular disease<sup>☆</sup>.

Current opinion in physiology·2026
Same author

Surface-Modified Electrospun Polyurethane Tubular Scaffold for Engineering Renal Proximal Tubule Constructs.

Journal of biomedical materials research. Part A·2026
Same author

Activated carbon fiber (ACF) as a dual respirator media for particulate matter (PM) filtration and volatile organic compound (VOC) adsorption.

Journal of occupational and environmental hygiene·2026
Same author

Cold plasma process ensnares fibrin-rich clots in an adhesive web.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences·2025

Related Experiment Video

Updated: Jun 16, 2026

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
09:32

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

Aligned bioactive multi-component nanofibrous nanocomposite scaffolds for bone tissue engineering.

Moncy V Jose1, Vinoy Thomas, Yuanyuan Xu

  • 1Department of Materials Science and Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA. moncyvj@uab.edu

Macromolecular Bioscience
|January 30, 2010
PubMed
Summary

This study developed aligned nanofibrous scaffolds for bone tissue engineering using collagen and nano-hydroxyapatite. Scaffolds showed improved properties at low nano-hydroxyapatite concentrations, supporting cell growth and protein adsorption.

More Related Videos

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
07:14

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Published on: July 27, 2022

Decellularized Apple-Derived Scaffolds for Bone Tissue Engineering In Vitro and In Vivo
09:49

Decellularized Apple-Derived Scaffolds for Bone Tissue Engineering In Vitro and In Vivo

Published on: February 23, 2024

Related Experiment Videos

Last Updated: Jun 16, 2026

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
09:32

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
07:14

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Published on: July 27, 2022

Decellularized Apple-Derived Scaffolds for Bone Tissue Engineering In Vitro and In Vivo
09:49

Decellularized Apple-Derived Scaffolds for Bone Tissue Engineering In Vitro and In Vivo

Published on: February 23, 2024

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Nanotechnology

Background:

  • Successful tissue engineering scaffolds must mimic the natural extracellular matrix.
  • Mimicking chemical, physical, and mechanical properties is crucial for scaffold efficacy.

Purpose of the Study:

  • To fabricate aligned nanofibrous multi-component scaffolds for bone tissue engineering.
  • To evaluate the effect of nano-hydroxyapatite (nano-HA) incorporation on scaffold properties.
  • To assess scaffold biocompatibility and protein adsorption capabilities.

Main Methods:

  • Electrospinning technique used to fabricate aligned nanofibrous scaffolds.
  • Incorporation of collagen, nano-hydroxyapatite, and poly[(D,L-lactide)-co-glycolide].
  • Evaluation of morphology, mechanical properties, thermal analysis, in vitro cell culture, and protein adsorption.

Main Results:

  • Low concentrations of nano-HA acted as a reinforcing agent, while higher concentrations led to aggregation and detrimental effects.
  • Scaffolds supported cell adhesion, spreading, and alignment along fiber direction.
  • Enhanced protein adsorption observed due to increased surface area and nano-HA presence.
  • Crosslinking improved mechanical properties and degradation stability.

Conclusions:

  • Aligned nanofibrous scaffolds composed of collagen, nano-HA, and PLGA show promise for bone tissue engineering.
  • Optimizing nano-HA concentration is critical for achieving desired mechanical reinforcement.
  • Scaffolds demonstrate good biocompatibility and promote cellular alignment, indicating potential for guided tissue regeneration.