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Updated: Jun 16, 2026

Gamete Collection and In Vitro Fertilization of Astyanax mexicanus
Published on: May 25, 2019
[The GATA family in reproduction]
Cai-xia Jing1, Jia-zhou Yang, Qing-yan Ai
1Department of Parasitology, West China School of Preclinical and Forensic Medicine, Sichuan University, Cheng-du, Sichuan 610041, China.
Abstract:
The GATA family proteins are a group of zinc finger transcription factors that are expressed in human and mammalian animals and play an important role in mammalian organ morphogenesis, cell proliferation and sex differentiation. GATA-4 and GATA-6 have been identified in the ovaries and testes of humans, mice, pigs and chickens. GATA-4 contributes to fetal male gonadal development by regulating the genes that mediate Müllerian duct regression and the onset of testosterone production. GATA-4 and GATA-6 are localized in and regulate the function of the ovarian and testicular somatic cells of fetal mice, especially granulosa cells, thecal cells, Sertoli cells and Leydig cells. GATA-4 is also present in the germ cells of fetal and prepubertal mice.
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